Molecular Sieves
Medchemexpress LLC Semaphorin-3A/SEMA3A 10ug
Recombinant rat Semaphorin-3A is supplied lyophilized and formulated for stability; it is expressed in E. coli with an N-terminal 6xHis tag and is intended for research on axon guidance and semaphorin signaling.
- Recombinant rat semaphorin-3a expressed in E. coli with an N-terminal 6xHis tag.
- Approximately 90.6 kDa molecular weight, >90% purity by reducing SDS-PAGE.
- Lyophilized formulation containing trehalose to enhance shelf stability.
- Stable at -20°C for up to two years; reconstituted stability 4°C for 1 week or -20°C for longer with carrier protein.
- Do not reconstitute below 100 μg/mL in ddH2O to maintain recommended concentration.
- Intended for in vitro studies of axon guidance and semaphorin signaling pathways.
Medchemexpress LLC Nutlin-3a (Rebemadlin) | 675576-98-4 | 581.49 g/mol | C30H30Cl2N4O4 | 500 MG
Nutlin-3a (Rebemadlin) is a research-grade small molecule that antagonizes MDM2, disrupting the MDM2-p53 interaction to stabilize wild-type p53 and trigger apoptosis and autophagy. It is used in preclinical studies to probe p53-dependent cancer biology and cellular stress responses.
- Inhibits MDM2-p53 interaction.
- Stabilizes wild-type p53 protein.
- Induces apoptosis and autophagy in p53-competent cells.
- Reported IC50 approximately 90 nM in biochemical assays.
- Molecular formula C30H30Cl2N4O4; molecular weight 581.49 g/mol.
- Suitable for in vitro and preclinical research applications.
Medchemexpress LLC Semaphorin-3A (SEMA3A) protein, mouse, Fc-tag | >95.0% | 500 UG
Recombinant mouse Semaphorin-3A (SEMA3A) is supplied as an N-terminal human Fc-tagged protein expressed in HEK293 cells for in vitro research. The protein is glycosylated, with an apparent molecular weight of approximately 80-95 kDa, and is available in sizes up to 500 μg.
- Purity greater than 95% by reducing SDS-PAGE.
- N-terminal human Fc tag facilitates detection and capture.
- Expressed in HEK293 to preserve mammalian glycosylation.
- Glycosylated molecular weight approximately 80-95 kDa.
- Store at -20°C; aliquot and freeze at -80°C for long-term storage.
Apexbio Technology LLC SMI-4a 438190-29-5 10mg
SMI-4a (CAS 438190-29-5) is a selective inhibitor of the serine/threonine kinase Pim-1 exhibiting an IC50 of 17 nM Pim-1 is implicated in the regulation of cell cycle progression and apoptosis with its overexpression associated with enhanced cell survival in various malignancies SMI-4a demonstrates increased activity compared to related compounds and inhibits downstream mTORC1 signaling and activates AMPK in leukemia cell lines leading to cell cycle arrest and apoptosis induction In preclinical studies SMI-4a reduced tumor volume in xenograft mouse models highlighting its utility for investigating Pim kinase-driven pathways in cancer research
Apexbio Technology LLC TCS-PIM-1-4a 327033-36-3 100mg
TCS-PIM-1-4a is a small-molecule inhibitor targeting Pim kinases a family of serine/threonine kinases It is designed to selectively inhibit Pim kinases thereby modulating signaling pathways related to cell growth and survival TCS-PIM-1-4a exerts its biological activity primarily through activation of AMP-activated protein kinase (AMPK) resulting in inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway In cell-based studies TCS-PIM-1-4a demonstrates cytotoxic activity against diverse hematological tumor cell lines including myeloid and lymphoid subtypes with IC50 values ranging from approximately 0 8 to 40 M Based on these pharmacological properties TCS-PIM-1-4a holds research potential in investigations of Pim kinase signaling and therapeutic strategies for hematological malignancies
Medchemexpress LLC Semaphorin-3A (SEMA3A) protein | >95.0% | 5 UG
Recombinant semaphorin-3A (SEMA3A) is a secreted axon guidance and cell-signaling protein supplied as a research reagent. The product is provided as a small purified preparation intended for in vitro assays, cell biology studies, and biochemical characterization. Purity is reported by the manufacturer as greater than 95% by reducing SDS-PAGE.
- Recombinant protein suitable for research use only.
- Expressed in HEK293 cells to support eukaryotic post-translational modifications.
- Fc-tagged format to aid detection and dimerization where applicable.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Supplied in a small, lyophilized preparation for convenient storage.
Medchemexpress LLC 3α-Aminocholestane | 2206-20-4 | 98.0% | 387.68 | 1 ML
3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM. It is for research use only.
- Effectively reduces OPM2 cell viability
- Blocks cell cycle progression in G0/G1 phase in RPMI8226 and U266 cells
- Reduces multiple myeloma (MM) growth in NOD/SCID/γcIL2R (NSG) mice
- Significantly enhanced survival of mice after tumor challenge
- Exhibits antiviral activity against Influenza A/PR8/34 (H1N1) virus in MDCK2 cells
Medchemexpress LLC 3α,12β-Dihydroxycholanoic acid | 570-62-7 | 97.0% | 392.57 | 1 ML
3α,12β-Dihydroxycholanoic acid is a bile acid that can be isolated from urine specimens of healthy humans. It is for research use only, and not sold to patients.
- Endogenous metabolite
- Appearance: Solid, white to off-white
- Structure classification: Steroids
- Initial source: Endogenous metabolite
Apexbio Technology LLC SMI-4a 438190-29-5 50mg
SMI-4a (CAS 438190-29-5) is a selective inhibitor of the serine/threonine kinase Pim-1 exhibiting an IC50 of 17 nM Pim-1 is implicated in the regulation of cell cycle progression and apoptosis with its overexpression associated with enhanced cell survival in various malignancies SMI-4a demonstrates increased activity compared to related compounds and inhibits downstream mTORC1 signaling and activates AMPK in leukemia cell lines leading to cell cycle arrest and apoptosis induction In preclinical studies SMI-4a reduced tumor volume in xenograft mouse models highlighting its utility for investigating Pim kinase-driven pathways in cancer research
Apexbio Technology LLC CU CPT 4a 1279713-77-7 5mg
CU CPT 4a (CAS 1279713-77-7) is a small-molecule inhibitor that selectively targets Toll-like receptor 3 (TLR3) It disrupts TLR3-mediated signaling by blocking the interaction between TLR3 and double-stranded RNA (dsRNA) thereby suppressing downstream pathways In RAW 264 7 cells CU CPT 4a demonstrates an IC50 of 3 44 M for TLR3 inhibition and significantly reduces the production of pro-inflammatory cytokines including TNF- and IL-1 In murine models administration of CU CPT 4a has been shown to protect crypt cells from death and decrease the severity of radiation-induced gastrointestinal syndrome This compound is valuable for research into TLR3-related inflammatory and radiation injury mechanisms
Medchemexpress LLC 3α-Aminocholestane | 2206-20-4 | 98.0% | 387.68 | 25 MG
3α-Aminocholestane is a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) inhibitor with an IC50 of ~2.5 μM. It is for research use only and not sold to patients.
- Appears as a white to off-white solid
- Stored at -20°C for 3 years or 4°C for 2 years as powder
- Stored at -80°C for 2 years or -20°C for 1 year in solvent
- Soluble in ethanol (50 mg/mL), slightly soluble in DMSO
- Exhibits antiviral activity against Influenza A/PR8/34 (H1N1) virus in MDCK-II cells
- Reduces OPM2 cell viability
- Blocks cell cycle progression in G0/G1 phase in RPMI8226 and U266 cells
- Reduces multiple myeloma (MM) growth in vivo and enhances survival of mice